Isolation and Properties of B(12) Coenzymes Containing Benzimidazole or Dimethylbenzimidazole.

نویسندگان

  • H Weissbach
  • J Toohey
  • H A Barker
چکیده

2 Ibid., 45, 136-144 (1959). 3 Weil-Malherbe, H., Biochem. J., 40, 351-363 (1946). 4 Isenberg, I., and A. Szent-Gyorgyi, PROC. NATL. ACAD. Sci., 44, 857-862 (1958). 5 Fujimori, E., PROC. NAT. ACAD. Sci., 45, 133-136 (1959). 6 Biochemisches Taschenbuch, ed. H. M. Rouen (Springer-Verlag, 1956). 7 Mason, S. F., Chapter in Ciba Foundation Symposium on Chemistry and Biology of Pteridines, ed. G. E. W. Wolstenholme and M. P. Cameron (Little Brown and Company, 1954).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Isolation and properties of crystalline cobamide coenzymes containing benzimidazole or 5, 6-dimethylbenzimidazole.

The isolation of three cobamide coenzymes has been briefly reported (1, 2). Methods used in the assay and purificat.ion of the adenylcobamide coenzyme have been described in some detail (3). This paper describes methods used in the isolation of the benzimidazolylcobamide and 5,6-dimethylbenzimidazolylcobamide coenzymes, both of which have been obtained as crystalline products. Some properties o...

متن کامل

Inhibition of heme synthesis by methyl-substituted benzimidazoles in vitro.

Emerson and associates (1) noted that 2,5-dimethylbenzimidazole appeared to act as a growth depressant when fed to rats in tests of compounds for vitamin Blz-like activity. This property was not exhibited by benzimidazole or any of the other monoor dimethylbenzimidazoles studied. They remarked that 2,5-dimethylbenzimidazole might have “inhibitor activity.” 2,5-Dimethylbenzimidazole inhibited re...

متن کامل

Inhibition of Influenza Virus Multiplication by 2,5-Dimethylbenzimidazole *

It can be postulated that the striking biological specificity shown by viruses is determined by or associated with certain specific nucleoproteins contained in the viral particle. If this be true, then it might be possible to inhibit viral multiplication without interfering with the function of host cell nucleoproteins, provided that sufficiently selective means were available. Such means are n...

متن کامل

Structure of cobamide coenzymes: influence of pH on absorption spectra and ionophoretic mobilities.

The absorption spectra of the 5,6-dimethylbenaimidazolylcobamide coenzyme (coenzyme Blz) and its benzimidaeolecontaining analogue (benzimidazolylcobamide coenzyme) are different from that of the adenine-containing analogue (adeninylcobamide’ coenzyme (1, 2)). The most conspicuous difference is in the wave length of the absorbancy maximum in the visible region. The spectra of the two benzimidazo...

متن کامل

Substrate specificity of the purine-2'-deoxyribonucleosidase of Crithidia luciliae.

The purine-2'-deoxyribonucleosidase of Crithidia luciliae catalyses an efficient deoxyribosyl transfer between a variety of purine bases, benzimidazole and 5,6-dimethylbenzimidazole. Since the deoxyriboside of a deoxyribosyl acceptor is necessarily also a substrate, the trans-N-deoxyribosylase activity of the enzyme allows a study of its specificity to be extended to a large number of purines a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 45 4  شماره 

صفحات  -

تاریخ انتشار 1959